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Kariko, K. Immunity 23 , — Anderson, B. Nucleic Acids Res. Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridine-containing mRNA encoding erythropoietin. Deleavey, G.

Chemical modification of siRNA. Nucleic Acid Chem. Mehier-Humbert, S. Physical methods for gene transfer: improving the kinetics of gene delivery into cells. Drug Deliv. Wells, D. Gene therapy progress and prospects: electroporation and other physical methods. Newman, C. Gene therapy progress and prospects: ultrasound for gene transfer. Plank, C. The magnetofection method: using magnetic force to enhance gene delivery.

Zhang, G.


  • Advances in Non-Viral DNA Vectors for Gene Therapy.
  • About the book.
  • Si lo sé no me caso (13/20) (Spanish Edition).

Naked DNA gene transfer in mammalian cells. Methods Mol. Li, W. Lipid-based nanoparticles for nucleic acid delivery. Thomas, M. Non-viral gene therapy: polycation-mediated DNA delivery. Lee, C. Designing dendrimers for biological applications. Discher, D. Martin, M. Peptide-guided gene delivery. AAPS J. Sokolova, V.

Non viral gene delivery system

Inorganic nanoparticles as carriers of nucleic acids into cells. Kawabata, K. The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake.

Nonviral Vectors for Gene Therapy

McManus, J. Observation of a rectangular columnar phase in a DNA—calcium—zwitterionic lipid complex. Does calcium turn a zwitterionic lipid cationic? B , — Koltover, I. Science , 78—81 This paper elucidates structural considerations involved in the endosomal escape of DNA mediated by liposomal nanoparticles. Wiethoff, C. Barriers to nonviral gene delivery. Morille, M.

Progress in developing cationic vectors for non-viral systemic gene therapy against cancer. Biomaterials 29 , — Capecchi, M. High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Cell 22 , — Miller, A. Tissue-specific and transcription factor-mediated nuclear entry of DNA.

Varga, C. Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes. Dinh, A. Understanding intracellular transport processes pertinent to synthetic gene delivery via stochastic simulations and sensitivity analyses. Wasungu, L. Cationic lipids, lipoplexes and intracellular delivery of genes.

Release , — Godbey, W. USA 96 , — Breunig, M.

Nonviral Vectors for Gene Therapy, Part 1, Volume 53 - 2nd Edition

Gene delivery with low molecular weight linear polyethylenimines. Schaffer, D. Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. Cohen, R. Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection. Controlled Release , — Gill, D. Progress and prospects: the design and production of plasmid vectors. Wooddell, C. Sustained liver-specific transgene expression from the albumin promoter in mice following hydrodynamic plasmid DNA delivery.

Miao, C. Inclusion of the hepatic locus control region, an intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitro. Argyros, O. Kreiss, P. Plasmid DNA size does not affect the physicochemical properties of lipoplexes but modulates gene transfer efficiency. Darquet, A.

Minicircle: an improved DNA molecule for in vitro and in vivo gene transfer. A robust system for production of minicircle DNA vectors. Ehrhardt, A. A direct comparison of two nonviral gene therapy vectors for somatic integration: in vivo evaluation of the bacteriophage integrase phiC31 and the Sleeping Beauty transposase. Wu, S.

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PiggyBac is a flexible and highly active transposon as compared to Sleeping Beauty, Tol2, and Mos1 in mammalian cells. Aronovich, E. The Sleeping Beauty transposon system: a non-viral vector for gene therapy. Fraley, R. Felgner, P. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. USA 84 , — References 59 and 60 are the earliest studies to show lipid-mediated DNA delivery in vitro.

Whitehead, K. Knocking down barriers: advances in siRNA delivery. Lonez, C. Cationic liposomal lipids: from gene carriers to cell signaling. Lipid Res. Hersey, P.

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Intralesional immunotherapy for melanoma. Olins, D. Model nucleoprotein complexes: studies on the interaction of cationic homopolypeptides with DNA. Laemmli, U. Characterization of DNA condensates induced by poly ethylene oxide and polylysine. USA 72 , — Wu, G.

Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. Receptor-mediated gene delivery and expression in vivo. References 66 and 67 are among the first to investigate the possibility of targeted non-viral nucleic acid delivery in vitro and in vivo. Choi, Y. Polyethylene glycol-grafted poly-L-lysine as polymeric gene carrier. Release 54 , 39—48 Kim, S. Polylysine copolymers for gene delivery.